By Jose A. Plaza, Victor G. Prieto
This publication presents a finished, cutting-edge account of the function of immunohistochemistry within the analysis of pores and skin tumors, that's an important on condition that overlapping histologic positive aspects and weird morphologic adjustments may end up in enormous diagnostic uncertainty. The booklet experiences intimately the sensitivity and specificity of more often than not on hand antibodies and their development of immunostaining. readers will study while to reserve antibodies and the way to interpret findings. moreover, prognostic markers are evaluated and emphasis put on the pitfalls in general encountered while comparing those neoplasms. The textual content is complemented through a wealth of fabulous photos. worthwhile histograms and algorithms are integrated, and transparent assistance is supplied at the program and interpretation of much less primary antibodies and immunostains. Applied Immunohistochemistry within the review of epidermis Neoplasms will function an exceptionally invaluable source for training dermatopathologists and pathologists.
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Additional info for Applied Immunohistochemistry in the Evaluation of Skin Neoplasms
On histopathology, the neoplasm usually shows no connection with the epidermis or adnexal structures and appears as a relatively symmetric, well-circumscribed dermal nodule, which involves the full thickness of the dermis and sometimes extends to the subcutaneous fat. The tumor is composed of multiple interconnected solid aggregations of epithelial cells that are punctuated by small round spaces in the fashion of a sieve. The cells show round or oval, hyperchromatic, slightly pleomorphic nuclei, inconspicuous or absent nucleoli, granular chromatin, and scant eosinophilic cytoplasm [23, 94].
78. Sigel JE, et al. The utility of cytokeratin 5/6 in the recognition of cutaneous spindle cell squamous cell carcinoma. J Cutan Pathol. 2001;28(10):520–4. 79. Gray Y, et al. Squamous cell carcinoma detected by high-molecular-weight cytokeratin immunostaining mimicking atypical fibroxanthoma. Arch Pathol Lab Med. 2001;125(6):799–802. 80. Heintz PW, White Jr CR. Diagnosis: atypical fibroxanthoma or not? Evaluating spindle cell malignancies on sun damaged skin: a practical approach. Semin Cutan Med Surg.
40. Kazlouskaya V, et al. Expression of p16 protein in lesional and perilesional condyloma acuminata and bowenoid papulosis: clinical significance and diagnostic implications. J Am Acad Dermatol. 2013;69(3):444–9. 41. Harvey NT, Leecy T, Wood BA. Immunohistochemical staining for p16 is a useful adjunctive test in the diagnosis of Bowen’s disease. Pathology. 2013;45(4): 402–7. 42. Zhou L, et al. Expression of cyclin D1 and cyclin E significantly associates with human papillomavirus subtypes in Bowenoid papulosis.