Download Angiotensin II Receptor Blockade Physiological and Clinical by Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. PDF

By Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)

The dating among angiotensin II and high blood pressure used to be proven in 1898 while angiotensin II was once proven to modulate systemic blood strain. Over the intervening many years, a whole characterization of the renin-angiotensin approach (RAS) has been accomplished, and our figuring out of its biochemistry and body structure has resulted in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists able to controlling high blood pressure. extra lately, it was once proven that angiotensin II is secreted inside of sure tissues and that those tissue-specific structures function independently of the systemic RAS. the radical idea that angiotensin II regulates a few cardiovascular strategies which are unrelated to blood strain has renewed the curiosity of either easy and medical scientists in angiotensin II. The organization among angiotensin II and cardiac development, specifically, has indicated that cures at the moment in use for high blood pressure could have direct program to the remedy of middle failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg was once convened October 18-20, 1996 to ascertain the medical and uncomplicated points of angiotensin receptor biology as they observe to high blood pressure and center failure. furthermore, the aptitude therapy of those stipulations utilizing particular angio­ tensin receptor antagonists was once addressed in the context in their quick healing software and destiny potential.

Show description

Read Online or Download Angiotensin II Receptor Blockade Physiological and Clinical Implications PDF

Similar clinical books

Current Issues in Clinical Psychology: Volume 1

In January 1980 a 'Refresher direction in scientific Psychology' was once held in Liverpool. the purpose of the direction used to be to use a modern standpoint to problems with value and curiosity to medical psychologists in Britain, and extra in particular to manage to pay for the chance for previous graduates in medical psychology from Liverpool college to fulfill jointly to percentage their operating reviews.

Clinical and Biological Basis of Lung Cancer Prevention

Lung melanoma is a illness with pandemic public healthiness implications because it is now the prime reason for melanoma mortality through the international. This booklet effects from contemporary overseas organization for the learn of Lung melanoma (IASLC) Workshops on lung melanoma prevention. It moves a stability among contemplating public healthiness techniques to tobacco regulate and population-based screening, advances in scientific assessment of chemoprevention techniques, and the biology of lung carcinogenesis.

Good Clinical Practice I: Grundlagen und Strategie

Die Humanpharmakologie wendet heute differenziert Modelle zur Absch{tzung der Medikamentenwirksamkeit an, sie liefert Kernaussagen zur Vertr{glichkeit, sie standardisiert und optimiert Untersuchungsmethoden. Dasvorliegende Buch ist dem Schwerpunkt reliable medical perform gewidmet. Die dazu k}rzlich fertiggestellten europ{ischen Richtlinien bieten sich durch die Vorgabe einheitlicher Kriterien als Richtschnur f}r alle klinischen Pr}fungen an.

Nanoceramics in Clinical Use: From Materials to Applications

The sector of nanoceramics for biomedical purposes has skilled vital advances within the final 5 years. those advances are ordinarily concentrated within the box of recent nanostructured bioceramics capable of mimic nearly an identical biomineralization methods. moreover, there has additionally been major advances in nanoceramics as automobiles for exact drug supply and gene treatment.

Extra info for Angiotensin II Receptor Blockade Physiological and Clinical Implications

Example text

1996. Will Ang II Al be renoprotective in humans? Kidney Intern 50:684-692. 47. Roman RJ, Kaidunski ML, Scicli AG, Carretero DA. 1988. Infiuence ofkinins and angiotensin II on the regulation of papillary blood flow. Am J Physiol 255:F690-F698. 48. Price D, DeOliveira J, Fisher N, Hollenberg N. 1996. Contribution of Ang II to renal hemodynamics in healthy men: the renal vascular response to eprosartan, an Ang II antagonist. ASN Program Abstract #A1688 from 29th Annual Meeting in New Orleans, Nov.

With the AT! receptor blocked, this sequence could lead to unopposed activation of the AT2 receptor, with unknown but potentially negative consequences. Although all of these considerations favor ACE inhibition over Ang II AT 1 antagonist action, each is a construct based on a slim database, generally obtained in vitro. Perhaps the most important consideration in Ichikawa's 10 A. Pharmacological Interruption of Renin-Angiotensin in Hypertension analysis involved glomerular hemodynamics, especially glomerular capillary pressure, which for many goes beyond the construct level.

Hypertension clinics of any size rapidly accumulated a series of patients in whom hypertension is difficult to treat. The process in these patients is known as refractory or resistant hypertension. Such patients generally had very high blood pressure, often required three or more drugs to achieve even partial blood pressure control, and often had abnormalities of renal excretory functioneither as the primary reason for hypertension or as a consequence of prolonged, substantial blood pressure elevation.

Download PDF sample

Rated 4.11 of 5 – based on 41 votes