Download Androgens and Androgen Receptor: Mechanisms, Functions, and by Chung Bon-chu, Hu Meng-Chun (auth.), Chawnshang Chang (eds.) PDF

By Chung Bon-chu, Hu Meng-Chun (auth.), Chawnshang Chang (eds.)

Androgen Receptors is the main entire and recent quantity at the subject, together with discussions of the elemental mechanisms of androgen-androgen receptor activities, their roles within the androgen-related illnesses, and their strength scientific applications.
Key issues coated comprise:

-The discovery and cloning of the androgen receptor;
-Androgen receptor coregulators;
-Androgen similar genes and their consensus DNA reaction parts;
-Basic mechanism of motion together with practical analyses, mobile localization and phosphorylation experiences;
-Cross-talk to different sign transduction platforms;
-The fresh connections of androgens to women's ailments, equivalent to osteoporosis and ovarian cancer.

This e-book is of curiosity to scholars, simple scientists, and clinicians as either a learn advisor and reference of analysis within the androgen box. it might probably even be used as a sophisticated point textual content in endocrinology, urology, OBGYN, or oncology.

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Additional info for Androgens and Androgen Receptor: Mechanisms, Functions, and Clinical Applications

Example text

2001). , 200 I). The cause of these differing findings are currently unc1ear but may be the result of use of different cell lines and reporter constructs. AR has also been found to heterodimerize with ERa. , 1999) (Figure 3). , 2000). , 1999). , 1997c). The mechanism of AR-ERo. , 2000) . AR IN SEXUAL DIFFERENTIATION In the human, embryos of both genetic sexes develop identically during the first six weeks of gestation . During this period, the primordial germ cells migrate from the yolk sac enteroderm to the genital ridge and the formation of the primitive gonads occurs.

38 AR MUTATIONS IN ANDROGEN INSENSITIVITY SYNDROME Androgen insensitivity syndrome (AIS) is an archetypal hormone resistance disorder due to mutation of the AR gene. , 1995). , 2001). The phenotypic diversity of AIS reflects the degree to which mutations of AR impair its normal function . , 1995). However, because of the necessary role of AR in sexual development, AR defects are perhaps more readily detectable because they are often associated with a clinical manifestation. AR mutations associated with AIS may result from a complete or partial deletion of the AR gene, introduction of nonsense mutations or frameshifts resulting in a truncated protein , mutations causing aberrant RNA splicing, and introduction of amino acid substitutions.

Nat!. Acad. Sci. E. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. 1. Clin. Endocrino!. Metab . D. A. Phenotypic features, androgen receptor binding , and mutational analysis in 278 c1inical cases reported as androgen insensitivity syndrome. 1. Clin . Endocrino!. Metab . c. -A. Immunocytochemical localization of glucocorticoid receptor in human gingival fibroblasts and evidence for colocalization of glucocorticoid receptor with cytoplasmic microtubules. Eur.

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