Download An Introduction to Genetic Engineering by Dr Desmond S. T. Nicholl PDF

By Dr Desmond S. T. Nicholl

During this 3rd version of his renowned undergraduate-level textbook, Des Nicholl recognises sound clutch of easy rules is key in any advent to genetic engineering. for that reason, in addition to being completely up to date, the booklet additionally keeps its concentrate on the basic rules utilized in gene manipulation. The textual content is split into 3 sections: half I presents an creation to the appropriate easy molecular biology; half II, the equipment used to control genes; and half III, purposes of the know-how. there's a new bankruptcy dedicated to the rising value of bioinformatics as a different self-discipline. different extra good points comprise textual content packing containers, which spotlight very important facets of issues mentioned, and bankruptcy summaries, which come with goals and studying results. those, in addition to key notice listings, idea maps and a thesaurus, will permit scholars to tailor their research to fit their very own studying kinds and eventually achieve an organization grab of an issue that scholars typically locate tough.

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The genetic code Second base First base (5 end) U C A G U C A G Third base (3 end) Phe Phe Leu Leu Leu Leu Leu Leu Ile Ile Ile Met Val Val Val Val Ser Ser Ser Ser Pro Pro Pro Pro Thr Thr Thr Thr Ala Ala Ala Ala Tyr Tyr STOP STOP His His Gln Gln Asn Asn Lys Lys Asp Asp Glu Glu Cys Cys STOP Trp Arg Arg Arg Arg Ser Ser Arg Arg Gly Gly Gly Gly U C A G U C A G U C A G U C A G Note: Codons read 5 →3 ; thus, AUG specifies Met. The three-letter abbreviations for the amino acids are as follows: Ala, Alanine; Arg, Arginine; Asn, Asparagine; Asp, Aspartic acid; Cys, Cysteine; Gln, Glutamine; Glu, Glutamic acid; Gly, Glycine; His, Histidine; Ile, Isoleucine; Leu, Leucine; Lys, Lysine; Met, Methionine; Phe, Phenylalanine; Pro, Proline; Ser, Serine; Thr, Threonine; Trp, Tryptophan; Tyr, Tyrosine; Val, Valine.

The operator is the binding site for the repressor protein, encoded by the lacI gene (i). The repressor gene lies outside the operon itself and is controlled by its own promoter, Pi . Genes in prokaryotes tend to be grouped together in operons, with several genes under the control of a single regulatory region. 16:16 21 P1: SBT 9780521850063c02 22 CUUS128/Nicholl 978 0 521 85006 3 March 11, 2008 THE BASIS OF GENETIC ENGINEERING operon there are three genes that code for proteins (termed structural genes) and an upstream control region encompassing the promoter and a regulatory site called the operator.

Thus, the simple G · C and A · T base pairing (see Fig. 4) has profound implications for living systems and for the applications of recombinant DNA technology. DNA sequence elements can be used in genome mapping and DNA profiling in Chapters 10 and 12. 2 Genome organisation The C-value paradox and the sequence complexity of eukaryotic genomes raise questions about how genomes are organised. Viral and bacterial genomes tend to show very efficient use of DNA for encoding their genes, which is a consequence of (and explanation for) their small genome size.

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