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The increasing use of atypical antipsychotics may also be relevant. qxd 5/5/04 5:33 PM Page 22 22 ADVERSE SYNDROMES AND PSYCHIATRIC DRUGS: A CLINICAL GUIDE has been a decrease in the reported mortality rates. Studies of NMS before 1984 quote mortality rates of up to 30 per cent but in more recent studies death is a rare occurrence (Keck et al. 1991; Bristow and Kohen 1993; Kohen and Bristow 1996). The more benign course may be due to better recognition of the syndrome and more appropriate treatment and management methods.

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