Download Advances in Immunology 50 by Frank J. Dixon PDF

By Frank J. Dixon

The fiftieth quantity in a monographic sequence on immunology. one of the subject matters coated listed below are avian T-cell ontogeny, adoptive move of human lymphoid cells to significantly immuno-deficient mice and histamine-releasing components and cytokine-dependent activation of basophils and mast cells.

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1989). In addition, a role for CD8 suppressor cells has not been ruled out. Why a signal that elicits strong T cell activation in tissue culture should induce deletion and/or inactivation in uiuo is also not known. This is a very interesting problem in T cell biology. An alternative approach to this problem is to examine mature peripheral T cells expressing Vp-encoded receptors that should lead to a response to self Vbse. , 1988). Thus, not all self- 36 CHARLES A. JANEWAY, JR. tolerance to Vbse is due to clonal deletion; at least a fraction is due to clonal anergy.

Gene knockout experiments may reveal nonpolymorphic Vbse that act together with I-A to delete developing T cells. Alternatively, one may argue that deletion of developing T cells by Vbse that work in concert with I-E are allowable, just as the absence of I-E is allowable, but that Vbse that delete developing T cells in association with I-A are not permissible just as I-A-negative mice have not been observed. The Vbse that associate with I-A may have too low an affinity for the Vp site on the TCR to cause frank deletion, as this effect would be too deleterious to the host.

Here, the crucial issues are which cells can respond to Vbse and which cells can elicit that response. Some ofthis material has been covered in the previous section as part of the argument for involvement of various molecules. A. THERESPONDING CELLS The response to Vbse is mediated by T cells; to date, only T cells expressing the a/pTCR have been detected in responses to both endogenous and bacterial Vbse. These cells do not proliferate in response to this stimulus. The precise meaning of this finding is unclear at present.

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